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pentobarbital will decrease the level or outcome of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Robust or average CYP3A inducers might lower cobimetinib systemic exposure by >eighty% and cut down its efficacy.Keep an eye on Closely (one)pentobarbital will lessen the level or impac